Tikhonova N T, Prokudina Iu A, Khrometskaia T M, Potemkina E E
Vopr Virusol. 1975 May-Jun(3):287-92.
Inoculation to children of live measles L-16 vaccine was found to cause changes in the content of the main serum classes of immunoglobulins, A, M and G, and synthesis of specific antibody of various physico-chemical nature. Between these two values only a relative correlation was observed at 10--14 and 28--32 days after vaccination. Changes in the synthesis of serum immunoglobulins in the majority of the children were not great and statistically insignificant. Only in 2 children with hypergammaglobulinemia inoculation of measles L-16 vaccine induced intensive (statistically significant) increase in serum M and G globulins. The results indicate the necessity of further study of the effects of live measles vaccine on the immunological status of children which could probably reveal the causes of occurrence of unusual postvaccination reactions and complications.
发现给儿童接种麻疹L-16活疫苗会导致血清中主要免疫球蛋白A、M和G的含量发生变化，以及不同理化性质的特异性抗体的合成发生变化。在接种疫苗后10 - 14天和28 - 32天，仅观察到这两个值之间存在相对相关性。大多数儿童血清免疫球蛋白合成的变化不大，且无统计学意义。只有2名患有高球蛋白血症的儿童接种麻疹L-16疫苗后，血清M和G球蛋白出现了显著（有统计学意义）的升高。结果表明有必要进一步研究麻疹活疫苗对儿童免疫状态的影响，这可能会揭示异常接种后反应和并发症发生的原因。
