Lisiewicz J, Astaldi G
Tumori. 1976 Nov-Dec;62(6):651-8. doi: 10.1177/030089167606200608.
Using the cytochemical method after Barka and Anderson, activity and localization of lysosomal acid phosphatase (AP) was determined in peripheral-blood lymphocytes from 20 healthy subjects, 10 patients with Hodgkin's disease (HD), 10 patients with plasma cell myeloma (PCM), and 10 patients with primary polycythemia (PP). Total count of AP-positive lymphocytes was lowest in the patients with HD. Moreover, they showed a significant decrease of the absolute count of lymphocytes with well formed and more numerous AP-positive lysosomal granules. Analogous alterations in lymphocytes from patients with PCM and those with PP were much less significant. The authors discuss the importance of the above-mentioned observations for evaluation on a cellular basis of lowered immunity of patients with lympho-proliferative and myelo-proliferative disorders, with special regard to AP as a T-cell marker.
采用巴尔卡和安德森之后的细胞化学方法，测定了20名健康受试者、10名霍奇金病（HD）患者、10名浆细胞骨髓瘤（PCM）患者和10名原发性红细胞增多症（PP）患者外周血淋巴细胞中溶酶体酸性磷酸酶（AP）的活性和定位。AP阳性淋巴细胞的总数在HD患者中最低。此外，他们显示出具有形态良好且数量较多的AP阳性溶酶体颗粒的淋巴细胞绝对计数显著减少。PCM患者和PP患者淋巴细胞中的类似改变则不太明显。作者讨论了上述观察结果对于在细胞基础上评估淋巴增殖性和骨髓增殖性疾病患者免疫力降低的重要性，特别提及AP作为一种T细胞标志物。
