Brusis T, Förster D, Grofe H J, Weuta H
Infection. 1977;5(1):26-31. doi: 10.1007/BF01639106.
Prior to tonsillectomy 57 selected patients were given 1 g azidocillin i.v. in the form of a 10% aqueous solution. Serum samples were drawn at different times after the injection and both the serum and the tonsils were examined for azidocillin activity. The results of examination of 133 serum samples and 111 tonsils were evaluated, in addition to 74 paired values for tonsils and serum. Serum levels attained a maximum of 230 microng/ml and remained within measurable range for at least six hours. Tonsil levels reached a maximum of 17 microng/g and after three hours began to drop below measurable range. The quotient for distribution between tonsils and serum rose during the first hour to 20-25% (average approx. 10%) and was about 3-6% three to four hours after injection.
在扁桃体切除术之前，对57名选定的患者静脉注射1克叠氮西林，采用10%水溶液的形式。在注射后的不同时间抽取血清样本，并对血清和扁桃体进行叠氮西林活性检测。除了74对扁桃体和血清的配对值外，还对133份血清样本和111个扁桃体的检测结果进行了评估。血清水平最高达到230微克/毫升，并在至少6小时内保持在可测量范围内。扁桃体水平最高达到17微克/克，3小时后开始降至可测量范围以下。扁桃体与血清之间的分布商在第一小时升至20%-25%（平均约10%），注射后三至四小时约为3%-6%。
