Byrén D, Engholm G, Englund A, Westerholm P
Environ Health Perspect. 1976 Oct;17:167-70. doi: 10.1289/ehp.17-1475258.
The cohort of workers employed in a Swedish vinyl chloride/poly(vinyl chloride) plant since its start in the early 1940's has been followed for mortality and cancer morbidity patterns. Only 21 of the 771 persons could not be traced. Difficulties in establishing exposure levels at different work areas in the past makes an evaluation of dose-effect relationships impossible. A four- to fivefold excess of pancreas/liver tumors was found, including two cases later classified as angiosarcomas of the liver. The number of brain tumors and suicide do not deviate significantly from expected. Cardiovascular and cerebrovascular diseases, on the other hand, differ significantly from the expected. The discrepancies between previous reports on VCM/PVC workers and this report are discussed. The possible etiology of the cardiovascular deaths is also discussed.
自20世纪40年代初一家瑞典氯乙烯/聚氯乙烯工厂开工以来，一直在跟踪该厂雇佣工人的死亡率和癌症发病率模式。771人中只有21人无法追踪到。过去在确定不同工作区域的接触水平方面存在困难，因此无法评估剂量-效应关系。发现胰腺/肝脏肿瘤有四到五倍的超额发病率，其中包括两例后来被归类为肝血管肉瘤的病例。脑肿瘤和自杀的数量与预期无显著差异。另一方面，心血管和脑血管疾病与预期有显著差异。讨论了先前关于氯乙烯/聚氯乙烯工人的报告与本报告之间的差异。还讨论了心血管死亡可能的病因。
