Molina G, Holmberg B, Elofsson S, Holmlund L, Moosing R, Westerholm P
Environ Health Perspect. 1981 Oct;41:145-51. doi: 10.1289/ehp.8141145.
Personnel lists from four PVC-processing industries were collected on production of employees with at least three months of employment at the beginning of 1945 and the last day of employment December 31, 1974. Of 2073 persons, 103 could not be followed up, because they had moved abroad. The remaining persons comprise the cohort of 1970 individuals who were analyzed and compared with the national population with respect to mortality from various diseases and cancer morbidity. The death risk from myocardial infarction is elevated in the cohort. This elevation is most clearly apparent in the subcohort which had at least two years of exposure time and where the analysis was directed at circumstances chronologically close to the time of exposure. The myocardial infarction risk related to vinyl chloride exposure is discussed in relation to earlier studies on the vascular effects of vinyl chloride. An indication of an elevated risk of morbidity and mortality from tumors in the digestive organs is also present. However, this is not statistically confirmed. A few future follow-ups of the present study are necessary in order to clarify any possible elevated risk of tumors in the PVC-processing industry.
收集了四个聚氯乙烯加工行业的人员名单，这些人员在1945年初至少已工作三个月，且在1974年12月31日为最后工作日。在2073人中，有103人因移居国外而无法追踪。其余人员组成了一个1970人的队列，对其进行了分析，并就各种疾病的死亡率和癌症发病率与全国人口进行了比较。该队列中心肌梗死的死亡风险有所升高。这种升高在至少有两年暴露时间且分析针对暴露时间前后相近情况的亚队列中最为明显。结合早期关于氯乙烯血管效应的研究，讨论了与氯乙烯暴露相关的心肌梗死风险。也有迹象表明消化器官肿瘤的发病和死亡风险有所升高。然而，这一点未得到统计学证实。为了明确聚氯乙烯加工行业中肿瘤风险是否可能升高，有必要对本研究进行一些后续追踪。
