氯乙烯和聚氯乙烯工人中的癌症发病率。
Incidence of cancer among vinyl chloride and polyvinyl chloride workers.
作者信息
Heldaas S S, Langård S L, Andersen A
出版信息
Br J Ind Med. 1984 Feb;41(1):25-30. doi: 10.1136/oem.41.1.25.
Abstract
The results of a follow up study of the incidence of cancer and the mortality in a cohort of 454 male workers producing vinyl chloride and polyvinyl chloride are presented. The study population was restricted to employees with more than one year's work experience in the study plant between 1950 and 1969 and the cohort was followed up from 1953 to the end of 1979. Twenty three new cases of cancer were observed compared with 20.2 expected; one case of liver angiosarcoma was found. Five cases of lung cancer were found (2.8 expected) and four cases of malignant melanoma of the skin were observed (0.8 expected). The possibility of a causal relationship between exposure to vinyl chloride and the development of malignant melanomas is discussed.
摘要
本文呈现了一项针对454名生产氯乙烯和聚氯乙烯的男性工人队列的癌症发病率及死亡率的随访研究结果。研究对象仅限于1950年至1969年间在研究工厂有一年以上工作经验的员工，该队列从1953年至1979年底进行随访。观察到23例新癌症病例，预期为20.2例；发现1例肝血管肉瘤。发现5例肺癌（预期2.8例），观察到4例皮肤恶性黑色素瘤（预期0.8例）。讨论了接触氯乙烯与恶性黑色素瘤发生之间存在因果关系的可能性。
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