Saper C B, Swanson L W, Cowan W M
J Comp Neurol. 1978 Dec 15;182(4):575-99. doi: 10.1002/cne.901820402.
The general morphology and topographic relations of the anterior hypothalamic area (AHA) in the rat, cat and squirrel monkey have been described, and its efferent connections analyzed autoradiographically, after small injections of 3H-labeled amino acids into, or around, the area. In all three species the AHA is rather poorly separated from the surrounding preoptic and hypothalamic areas and nuclei but shows three distinct cellular condensations, located rostrally, centrally, and posterodorsally. Closely associated with the AHA are the retrochiasmatic area, the anterior periventricular nucleus and the scattered neurons usually referred to as the accessory supraoptic nucleus. The AHA has primarily short connections to the adjoining medial preoptic area, the lateral hypothalamic area, the periventricular nucleus, the dorsomedial nucleus, and to the "capsule" of the ventromedial nucleus. However, it also has certain more distant projections, rostrally to a narrow zone centered in the ventral part of the lateral septal nucleus, and caudally to the dorsal premammillary nuclei, the posterior hypothalamic area and the central gray. There is some evidence to suggest that the various subdivisions of the AHA have different efferent connections. Thus the posterodorsal cell condensation appears to give rise to the bilateral projection to the dorsal premammillary nuclei, while the projections to the septum, the posterior hypothalamic area and the central gray seem to have their origin in the central condensation. Similarly, the retrochiasmatic area sends its efferents through the ventral supraoptic commissure to the amygdala, the anterior periventricular nucleus contributes to the periventricular fiber system and to the external lamina of the median eminence, and the accessory supraoptic neurons project to the internal lamina of the median eminence.
对大鼠、猫和松鼠猴下丘脑前区（AHA）的大体形态和局部关系进行了描述，并在该区域或其周围小剂量注射³H标记的氨基酸后，通过放射自显影分析了其传出连接。在所有这三个物种中，AHA与周围的视前区和下丘脑区域及核团的界限相当不清晰，但呈现出三个明显的细胞密集区，分别位于吻侧、中央和后背部。与AHA紧密相关的是视交叉后区、室周前核以及通常被称为视上核旁核的散在神经元。AHA主要与相邻的内侧视前区、外侧下丘脑区、室周核、背内侧核以及腹内侧核的“被膜”有短连接。然而，它也有一些更远距离的投射，吻侧投射到以外侧隔核腹侧部分为中心的一个狭窄区域，尾侧投射到背内侧乳头前核、下丘脑后区和中央灰质。有证据表明，AHA的各个亚区具有不同的传出连接。因此，后背部细胞密集区似乎产生了向双侧背内侧乳头前核的投射，而向隔区、下丘脑后区和中央灰质的投射似乎起源于中央密集区。同样，视交叉后区通过腹侧视上连合将其传出纤维投射到杏仁核，室周前核参与室周纤维系统和正中隆起的外层，视上核旁神经元投射到正中隆起的内层。
