Jacotot B, Gero S
Pathol Biol (Paris). 1975 Nov;23(9):711-5.
Although the effects of prostaglandins (namely PGE) on lipolysis are well known, there are few data about their action on the various serum lipids (cholesterol, phospholipids, triglycerides). We have no information about the action of these products on experimental atherosclerosis and the arterial lipids. In the present work, we found in rabbits fed an hyperlipidemic diet, or receiving adrenalin injections, or a sequential atherogenic treatment for a long course, that the treatment by PGE1 induces a decrease of the serum lipids, mainly in animals fed an hyperlipidemic diet. In the same experiment, we found also a decrease of the cholesterol level in aorta and in the connective tissue of sub-cutaneous granulomas. The interest of these findings is discussed in the light of present known data about the effect of prostaglandins on lipid metabolism.
尽管前列腺素（即PGE）对脂肪分解的作用已为人熟知，但关于它们对各种血清脂质（胆固醇、磷脂、甘油三酯）作用的数据却很少。我们没有这些产物对实验性动脉粥样硬化和动脉脂质作用的相关信息。在本研究中，我们发现，在喂食高脂饮食的兔子中，或接受肾上腺素注射的兔子中，或长期接受连续致动脉粥样硬化治疗的兔子中，PGE1治疗可导致血清脂质降低，主要是在喂食高脂饮食的动物中。在同一实验中，我们还发现主动脉和皮下肉芽肿结缔组织中的胆固醇水平有所降低。结合目前已知的关于前列腺素对脂质代谢影响的数据，对这些发现的意义进行了讨论。
