Chaialo P P
Vopr Med Khim. 1978 Nov-Dec;24(6):806-11.
Content of cholesterol, tryglycerides and phospholipids in blood and liver tissue as well as the rate of their biosynthesis in liver tissue were studied in young (8-12 months old) and old (42-48 months old) rabbits in normal state and in dynamics of experimental atherosclerosis within 10-15 and 25-30 days. The rate of biosynthesis of these lipids was decreased in liver tissue with ageing. In maintaining of animals at atherogenic diet the most distinct impairments of lipid metabolism were observed in 42-48 months old rabbits, especially in those of the 25-30 days group. Considerable accumulation of cholesterol in liver tissue of old rabbits was accompanied by inhibition of its biosynthesis and by more distinct hypercholesterolemia in blood.
研究了正常状态下以及在10 - 15天和25 - 30天实验性动脉粥样硬化动态过程中，年轻（8 - 12个月大）和年老（42 - 48个月大）兔子血液和肝脏组织中胆固醇、甘油三酯和磷脂的含量及其在肝脏组织中的生物合成速率。随着年龄增长，肝脏组织中这些脂质的生物合成速率降低。在给动物喂食致动脉粥样化饮食时，42 - 48个月大的兔子脂质代谢受损最为明显，尤其是在25 - 30天组的兔子中。老年兔子肝脏组织中胆固醇的大量积累伴随着其生物合成的抑制以及血液中更明显的高胆固醇血症。
