[Relationship between age and the character of changes in several liver lipid metabolism indices in the early stages of experimental atherosclerosis].

Content of cholesterol, tryglycerides and phospholipids in blood and liver tissue as well as the rate of their biosynthesis in liver tissue were studied in young (8-12 months old) and old (42-48 months old) rabbits in normal state and in dynamics of experimental atherosclerosis within 10-15 and 25-30 days. The rate of biosynthesis of these lipids was decreased in liver tissue with ageing. In maintaining of animals at atherogenic diet the most distinct impairments of lipid metabolism were observed in 42-48 months old rabbits, especially in those of the 25-30 days group. Considerable accumulation of cholesterol in liver tissue of old rabbits was accompanied by inhibition of its biosynthesis and by more distinct hypercholesterolemia in blood.