[再生大鼠肝脏中多胺与DNA合成的可逆性紊乱]
[Reversible disorder of polyamine and DNA synthesis in regenerating rat liver].
作者信息
Mikhaĭlovskiĭ V O, Tsiakalo L V, Gulyĭ M F
出版信息
Biull Eksp Biol Med. 1980 Aug;90(8):165-7.
A single injection of diaminohexane (DAH) causes an abrupt but reversible decrease in the putrescine concentration in the regenerating rat liver. Under experimental conditions hepatic spermidine and spermin content remains invariable while the synthesis of these compounds temporarily decreases. Incorporation of the radioactive precursors into proteins and RNA of the regenerating liver does not essentially change after DAH injection. However, DNA synthesis is sharply reduced. Incorporation of 3H-thymidine into DNA directly correlates with the putrescine concentration and spermidine synthesis. The results suggest that putrescine is essential for maintenance of normal DNA replication in the regenerating rat liver.
单次注射二氨基己烷（DAH）会使再生大鼠肝脏中的腐胺浓度突然但可逆地降低。在实验条件下，肝脏中的亚精胺和精胺含量保持不变，而这些化合物的合成暂时减少。注射DAH后，放射性前体掺入再生肝脏的蛋白质和RNA中基本没有变化。然而，DNA合成急剧减少。3H-胸腺嘧啶掺入DNA与腐胺浓度和亚精胺合成直接相关。结果表明，腐胺对于维持再生大鼠肝脏中正常的DNA复制至关重要。
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