Aitken I D, Parry S H
Immunology. 1976 Jul;31(1):33-7.
Three-week-old chickens were given sheep erythrocytes or bovine serum albumin intravenously. Seven days later their tears and saliva possessed low levels of antibody to those antigens. Concurrent infection with lentogenic Newcastle disease virus (NDV) caused a significant increase in transuded antibody in those fluids. In chickens with circulating antibody to NDV, induced by parenterally administered inactivated vaccine, respiratory infection with heterologous infectious bronchitis virus resulted in limited transudation of anti-NDV. In contrast, the tears, saliva and tracheal fluid of non-vaccinated chickens undergoing primary infection with NDV acquired considerable levels of specific anti-NDV. The difference between the two groups is attributed to locally synthesized antibody.
给三周龄的鸡静脉注射绵羊红细胞或牛血清白蛋白。七天后，它们的眼泪和唾液中针对这些抗原的抗体水平较低。同时感染弱毒新城疫病毒（NDV）会导致这些体液中渗出抗体显著增加。在经胃肠外接种灭活疫苗诱导产生针对NDV循环抗体的鸡中，感染异源传染性支气管炎病毒会导致抗NDV的渗出有限。相比之下，初次感染NDV的未接种疫苗鸡的眼泪、唾液和气管液中获得了相当高水平的特异性抗NDV。两组之间的差异归因于局部合成的抗体。
