Durán J A, Sánchez A, Serrano M I, Serrano J S
Clinical Pharmacology Department, University Hospital, Medical School, Seville, Spain.
Methods Find Exp Clin Pharmacol. 1988 May;10(5):337-40.
Phenobarbital plasma level/dose ratio (L/D) has been studied in 536 outpatients distributed in groups according to age, sex and drug dosage. Samples were obtained prior to the first morning dose. Plasma levels that correspond to the steady-state phase were determined by homogeneous enzymatic immunoassay (EMITR). From the results it must be pointed out: 1) An increase of L/D as the age increases within each group; 2) A decrease of L/D as the dose of phenobarbital increases in the overall sample; 3) Sex does not affect L/D in any of the subgroups studied; 4) For a given dose higher blood levels are reached in children 7 to 15 years old in our sample than in other comparable studies in Spain.
已对536名门诊患者的苯巴比妥血药浓度/剂量比（L/D）进行了研究，这些患者根据年龄、性别和药物剂量分组。样本在首个早晨剂量前采集。通过均相酶免疫分析（EMITR）测定对应稳态期的血药浓度。从结果中必须指出：1）每组中L/D随年龄增加而升高；2）总体样本中L/D随苯巴比妥剂量增加而降低；3）在所研究的任何亚组中，性别均不影响L/D；4）对于给定剂量，我们样本中7至15岁儿童的血药浓度高于西班牙其他类似研究中的儿童。
