Maas A I, de Lange S A
Clin Neurol Neurosurg. 1976;79(2):91-106. doi: 10.1016/0303-8467(76)90002-0.
The influence of Trimetaphan induced hypotension was studied on the development of increased ventricular fluid pressure after induction of cold injuries of the brain in cats. Hypotension was induced in two series of animals: in one immediately after freezing and in another series after a delay of three quarters of an hour. In the animals not treated with hypotension ventricular fluid pressure increased considerably according to three types of response. In both series treated with hypotension the ventricular fluid pressure and elastance were significantly lower than in the animals not treated; also brain stem herniation tended to occur less frequently in the animals treated. No deleterious effect of the hypotension was seen on cerebral metabolism as measured by the lactate content in the cerebrospinal fluid.
研究了咪噻芬诱导的低血压对猫脑冷损伤后心室液压力升高发展的影响。在两组动物中诱导低血压：一组在冷冻后立即诱导，另一组在延迟三刻钟后诱导。在未用低血压治疗的动物中，根据三种反应类型，心室液压力显著升高。在两组接受低血压治疗的动物中，心室液压力和弹性明显低于未治疗的动物；此外，接受治疗的动物中脑干疝形成的频率也较低。通过脑脊液中的乳酸含量测量，未发现低血压对脑代谢有有害影响。
