Maas A I
J Neurol Neurosurg Psychiatry. 1977 Sep;40(9):896-900. doi: 10.1136/jnnp.40.9.896.
The influence of trimetaphan-induced hypotension was studied on the increase in the activities of various enzymes in the cerebrospinal fluid after cold injuries of the brain in cats. Hypotension was induced immediately after freezing, and in a second series after a delay of 45 minutes. It was shown that induction of hypotension may inhibit the appearance of enzymes in the CSF after cold injuries in the first seven hours after freezing. Histological studies revealed less pronounced oedema in the hypotensive animals. The results suggest that hypotension retards the transport of enzymes released from necrotic areas through the extracellular fluid towards the CSF.
研究了咪噻芬诱导的低血压对猫脑冷损伤后脑脊液中各种酶活性增加的影响。在冷冻后立即诱导低血压，在第二组实验中，在延迟45分钟后诱导低血压。结果表明，诱导低血压可能会在冷冻后的前七个小时内抑制冷损伤后脑脊液中酶的出现。组织学研究显示，低血压动物的水肿不太明显。结果表明，低血压会延缓坏死区域释放的酶通过细胞外液向脑脊液的转运。
