Bednár B, Mann M
Cesk Patol. 1976 Aug;12(3):123-31.
Healing of cutaneous wounds produced on the backs of young and old rats has been compared at ten various intervals between days 3 and 28. The only differences disclosed pertained to the exsudative and proliferative phases between days 3 and 5, which were found to develop more rapidly in young rats. The phase of the (predominantly afibrillar) connection of the wound stumps was reduced to less than 5 days. The exact nature of the "sticking" intercellular substance has not been clarified; most probably the substance represents nonfibrillar collagen. In the group of old rats neoformation of fibrillary neocollagen was somewhat more marked during days 7 to 9 than in yound rats, in whom a rather pronounced exsudative component was found during that period. No significant differences between the two groups were disclosed during the later stages of the experiment. Fibroblasts participated in collagen phagocytosis during the definitive reconstruction of the provisional, imperfectly oriented fibrillar connection of the wound edges.
在第3天至第28天的十个不同时间间隔，对年轻和老年大鼠背部产生的皮肤伤口愈合情况进行了比较。所发现的唯一差异与第3天至第5天的渗出期和增殖期有关，发现年轻大鼠的这两个阶段发展得更快。伤口残端（主要是无纤维的）连接阶段缩短至不到5天。“粘性”细胞间物质的确切性质尚未阐明；很可能该物质代表无纤维胶原蛋白。在老年大鼠组中，第7天至第9天纤维状新胶原蛋白的新形成比年轻大鼠组更为明显，而在年轻大鼠组中，在此期间发现了相当明显的渗出成分。在实验后期，两组之间未发现显著差异。在伤口边缘临时的、排列不完美的纤维连接的最终重建过程中，成纤维细胞参与了胶原吞噬作用。
