Danon D, Kowatch M A, Roth G S
Weizmann Institute of Science, Rehovot, Israel.
Proc Natl Acad Sci U S A. 1989 Mar;86(6):2018-20. doi: 10.1073/pnas.86.6.2018.
Application of peritoneal macrophages to experimentally induced cutaneous wounds of old mice accelerates healing to levels almost comparable to those of untreated young animals. Slightly greater acceleration is observed when macrophages are obtained from young as opposed to old donors. These findings are consistent with a defect in macrophage function as a cause of impaired wound healing in senescence and suggest a possible therapeutic strategy.
将腹腔巨噬细胞应用于实验诱导的老年小鼠皮肤伤口，可加速伤口愈合，使其达到几乎与未处理的年轻动物相当的水平。与从老年供体获取的巨噬细胞相比，从年轻供体获取巨噬细胞时观察到的加速作用略强。这些发现与巨噬细胞功能缺陷是衰老过程中伤口愈合受损的原因一致，并提示了一种可能的治疗策略。
