Murphy M P
Department of Biochemistry, University of Otago, Box 56, Dunedin, New Zealand.
Biochim Biophys Acta. 1999 May 5;1411(2-3):401-14. doi: 10.1016/s0005-2728(99)00029-8.
Nitric oxide (NO) has several essential roles in mammals, but unregulated NO production can cause cell death through oxidative stress, disrupted energy metabolism, DNA damage, activation of poly(ADP-ribose) polymerase, or dysregulation of cytosolic calcium. Such disturbances can lead to either apoptotic or necrotic cell death, depending on the severity and context of the damage. Here I review the mechanisms by which NO kills cells and discuss how NO thereby contributes to ischaemia-reperfusion injury and neurodegeneration.
一氧化氮（NO）在哺乳动物中具有多种重要作用，但不受调控的NO生成可通过氧化应激、能量代谢紊乱、DNA损伤、聚（ADP-核糖）聚合酶激活或胞质钙失调导致细胞死亡。根据损伤的严重程度和背景情况，这些干扰可导致细胞凋亡或坏死性死亡。在此，我综述了NO杀死细胞的机制，并讨论了NO如何导致缺血-再灌注损伤和神经退行性变。
