Archer S Y, Hodin R A
Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA.
Curr Opin Genet Dev. 1999 Apr;9(2):171-4. doi: 10.1016/s0959-437x(99)80026-4.
In the past year, several papers have been published which implicate a link between alterations in chromatin structure and the development of cancer. Both histone hyperacetylation and hypoacetylation appear to be important in the neoplastic process, depending on the target gene involved. In the case of colon cancer, induction of the p21 gene by histone hyperacetylation may be a mechanism by which dietary fiber prevents carcinogenesis.
在过去的一年里，已经发表了几篇论文，这些论文表明染色质结构的改变与癌症的发展之间存在联系。组蛋白的高乙酰化和低乙酰化在肿瘤形成过程中似乎都很重要，这取决于所涉及的靶基因。就结肠癌而言，组蛋白高乙酰化诱导p21基因可能是膳食纤维预防致癌作用的一种机制。
