Devalaraja M N, Richmond A
Department of Cell Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Trends Pharmacol Sci. 1999 Apr;20(4):151-6. doi: 10.1016/s0165-6147(99)01342-5.
Recruitment of leukocytes either during development or to the site of injury is crucial. The molecular regulation of cell trafficking is complex but well orchestrated by the temporal and spatial expression of a multitude of chemokines (chemoattractant cytokines) and chemokine receptors. The chemokines, classified primarily into four classes (CC, C, CXC and CX3C) bind either to specific or shared receptors and often exhibit intra-class redundancy. At the cellular level, the biological activity of chemokines is finely controlled by varied receptor display, binding affinity and/or varied signal-transducing mechanisms. Perturbation in these finely regulated processes leads to acute or chronic inflammatory conditions, developmental abnormalities and tumorigenesis/angiogenesis.
在发育过程中或损伤部位募集白细胞至关重要。细胞迁移的分子调控很复杂，但由多种趋化因子（化学引诱细胞因子）和趋化因子受体的时空表达精心编排。趋化因子主要分为四类（CC、C、CXC和CX3C），它们与特定或共享的受体结合，且常常表现出类内冗余。在细胞水平上，趋化因子的生物学活性通过不同的受体展示、结合亲和力和/或不同的信号转导机制得到精细调控。这些精细调控过程中的紊乱会导致急性或慢性炎症、发育异常以及肿瘤发生/血管生成。
