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内分泌胰腺的昼夜节律。一项定量生化与免疫细胞化学研究。

Circadian rhythms of the endocrine pancreas. A quantitative biochemical and immumocytochemical study.

作者信息

Polak J M, Pearse A G, Van Mourik M, Mayersbach H V

出版信息

Acta Hepatogastroenterol (Stuttg). 1975 Apr;22(2):118-22.

PMID:1093349
Abstract

Cellular hormone levels of insulin and glucagon in the endocrine pancreas of the rat have been observed and quantified over the 24-hours period, at 3-hourly intervals, by T.V. image conversion analysis on immunocytochemical preparations. Parallel estimations of blood sugar were carried out. Glucagon levels were at their lowest when the blood sugar levels were at their highest. Quantitative cytochemistry is regarded as a valuable tool for the investigation of changes in intracellular hormone levels under physiological and pathological conditions.

摘要

通过对免疫细胞化学制剂进行电视图像转换分析,已在大鼠内分泌胰腺中观察并定量了24小时内每隔3小时胰岛素和胰高血糖素的细胞激素水平。同时进行了血糖的平行测定。当血糖水平最高时,胰高血糖素水平最低。定量细胞化学被认为是研究生理和病理条件下细胞内激素水平变化的一种有价值的工具。

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1
Circadian rhythms of the endocrine pancreas. A quantitative biochemical and immumocytochemical study.内分泌胰腺的昼夜节律。一项定量生化与免疫细胞化学研究。
Acta Hepatogastroenterol (Stuttg). 1975 Apr;22(2):118-22.
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引用本文的文献

1
Immunohistochemistry as an important tool in biomarkers detection and clinical practice.免疫组织化学作为生物标志物检测和临床实践中的一项重要工具。
Biomark Insights. 2010 Feb 9;5:9-20. doi: 10.4137/bmi.s2185.
2
Twenty-four hour variations in subcellular structures of rat pancreatic islet B-, A- and D-cells, and of portal plasma glucose and insulin levels.大鼠胰岛B细胞、A细胞和D细胞的亚细胞结构以及门静脉血浆葡萄糖和胰岛素水平的24小时变化。
Cell Tissue Res. 1988 Aug;253(2):337-45. doi: 10.1007/BF00222290.
3
Time -- a key in experimental and practical medicine.
时间——实验医学和临床医学的关键要素。
Arch Toxicol. 1976 Dec 17;36(3-4):185-216. doi: 10.1007/BF00340529.