Chiò A, Cucatto A, Calvo A, Terreni A A, Magnani C, Schiffer D
Department of Neuroscience, University of Turin and Azienda Ospedaliera San Giovanni Battista, Torino, Italy.
J Neurol. 1999 Mar;246(3):175-80. doi: 10.1007/s004150050330.
Recent surveys indicate a decreasing north-to-south gradient in the mortality and incidence rates of amyotrophic lateral sclerosis (ALS) in Italy, possibly indicating a different susceptibility to ALS in these populations. Piemonte, a region of northwestern Italy, experienced a considerable migration from other regions in Italy between 1940 and 1975; we therefore analyzed the effects of place of birth and migration upon the risk of developing ALS. Data on all ALS cases occurring in Piemonte during the period 1971-1990 were collected. Standardized incidence ratios (SIRs) for patients born outside Piemonte were calculated, using the Piemonte-born population as reference. A total of 962 ALS cases were identified during the study period, corresponding to a mean annual crude incidence rate of 1.37/100,000 population (95% confidence interval, 1.29-1.46). The SIRs of patients born in three southern Italian regions and of foreign-born persons were significantly higher than those of persons born in Piemonte and or other regions in Italy, and increased with age. This observation may be explained by an interaction between environmental and genetic factors or by selective migration.
最近的调查表明，意大利肌萎缩侧索硬化症（ALS）的死亡率和发病率呈南北梯度递减趋势，这可能表明这些人群对ALS的易感性不同。意大利西北部的皮埃蒙特地区在1940年至1975年间经历了来自意大利其他地区的大量移民；因此，我们分析了出生地和移民对患ALS风险的影响。收集了1971年至1990年期间皮埃蒙特地区所有ALS病例的数据。以出生在皮埃蒙特的人群为参照，计算出生在皮埃蒙特以外地区患者的标准化发病率（SIR）。在研究期间共确定了962例ALS病例，对应的年平均粗发病率为1.37/10万人口（95%置信区间，1.29 - 1.46）。出生在意大利南部三个地区的患者和外国出生者的SIR显著高于出生在皮埃蒙特和意大利其他地区的人，且随年龄增长而增加。这一观察结果可能是环境因素与遗传因素相互作用或选择性移民所致。
