Shibahara H, Mitsuo M, Fujimoto K, Muranaka J, Sawai H, Bessho T, Shigeta M, Koyama K
Department of Obstetrics and Gynecology, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan.
Hum Reprod. 1999 May;14(5):1324-7. doi: 10.1093/humrep/14.5.1324.
Here we report the first case of prenatally diagnosed fetal renal mesoblastic nephroma occurring after transfer of a cryopreserved embryo. A 37 year old woman, having immunological infertility, was treated by in-vitro fertilization (IVF) and embryo transfer. Following unsuccessful IVF using fresh embryos, the patient conceived after transfer of cryopreserved-thawed embryos. The chromosomal analysis identified a normal karyotype at 16 weeks' gestation when amniocentesis was performed. The pregnancy course was uneventful until 28 weeks' gestation when polyhydramnios associated with fetal renal tumour was detected using ultrasonography. A male infant weighing 2564 g was born via Caesarean section at 34 weeks' gestation. A left nephrectomy was performed 5 days after delivery and the tumour was identified histologically as a mesoblastic nephroma. The postoperative course was uncomplicated to this point.
在此，我们报告首例经冷冻保存胚胎移植后产前诊断出的胎儿肾中胚叶肾瘤病例。一名37岁患有免疫性不孕的女性接受了体外受精（IVF）及胚胎移植治疗。在使用新鲜胚胎进行体外受精失败后，该患者在移植冷冻解冻胚胎后受孕。孕16周行羊膜腔穿刺术时，染色体分析显示核型正常。妊娠过程一直顺利，直到孕28周时超声检查发现羊水过多并伴有胎儿肾肿瘤。孕34周时经剖宫产娩出一名体重2564 g的男婴。出生后5天行左肾切除术，肿瘤经组织学检查确诊为中胚叶肾瘤。至此，术后过程无并发症。
