Goodyear K, Lewith G, Low J L
School of Medicine, University Medicine, University of Southampton, UK.
J R Soc Med. 1998 Nov;91(11):579-82. doi: 10.1177/014107689809101108.
Homoeopathic drug pictures are developed by recording the symptomatic effects of homoeopathic remedies given to healthy volunteers (a 'proving'). In a double-blind randomized controlled trial we tested the hypothesis that individuals using an infinitesimal dilution of Belladonna (thirtieth potency, C30) would record more true symptoms, on a questionnaire that contained both true and false Belladonna proving symptoms, than those receiving placebo. 60 volunteers entered the study and 47 completed data collection. We were unable to distinguish between Belladonna C30 and placebo using our primary outcome measure. For the secondary outcome measure we analysed the number of individuals who proved to the remedy according to our predefined criteria: 4 out of 19 proved in the Belladonna C30 group and 1 out of 27 in the placebo group (difference not statistically significant). This pilot study does not demonstrate a clear proving reaction for Belladonna C30 versus placebo, but indicates how the question might be further investigated.
顺势疗法药物图像是通过记录给予健康志愿者的顺势疗法药物的症状效应（“验证”）而形成的。在一项双盲随机对照试验中，我们检验了这样一个假设：在一份包含真、假颠茄验证症状的问卷上，使用颠茄极微稀释液（三十次方药力，C30）的个体记录的真实症状会比接受安慰剂的个体更多。60名志愿者参与了该研究，47名完成了数据收集。使用我们的主要结局指标，我们无法区分颠茄C30和安慰剂。对于次要结局指标，我们分析了根据我们预先定义的标准对该药物产生验证反应的个体数量：颠茄C30组19人中有4人产生验证反应，安慰剂组27人中有1人产生验证反应（差异无统计学意义）。这项初步研究并未表明颠茄C30与安慰剂相比有明显的验证反应，但指出了该问题可如何进一步研究。
