Benson G A, Spillane W J
J Pharm Sci. 1976 Dec;65(12):1841-3. doi: 10.1002/jps.2600651237.
The nonnutritive sweetener sodium cyclopentylsulfamate was fed to Wistar albino rats and New Zealand White rabbits. Urine was collected for 3 days after feeding, combined, and examined for the metabolites cyclopentylamine, cyclopentanone, and cyclopentanol and for sodium cyclopentylsulfamate was assayed by hydrolysis in acidified dioxane-water and subsequent measurement of the absorbance of the product formed (lambdamax = 490 nm) by the liberated amine with p-benzoquinone. The average conversion to cyclopentylamine, cyclopentanone, and cyclopentanol was 0.103, 0.171, and 0.054% in the rabbit and 0.057, 0.016, and 0.008% in the rat, respectively.
将非营养性甜味剂环戊基氨基磺酸钠喂给Wistar白化大鼠和新西兰白兔。喂食后收集尿液3天，合并后检测代谢产物环戊胺、环戊酮和环戊醇，并通过在酸化的二氧六环 - 水中水解，随后用对苯醌测量释放的胺形成的产物的吸光度（λmax = 490 nm）来测定环戊基氨基磺酸钠。在兔子中，环戊基氨基磺酸钠平均转化为环戊胺、环戊酮和环戊醇的比例分别为0.103%、0.171%和0.054%，在大鼠中分别为0.057%、0.016%和0.008%。
