Spillane W J, Benson G A, McGlinchey G
J Pharm Sci. 1979 Mar;68(3):372-4. doi: 10.1002/jps.2600680333.
The nonnutritive sweeteners cyclooctylsulfamate and 4-methylcyclohexylsulfamate were fed separately to female Wistar albino rats, and the urine was examined for the possible metabolites cyclooctylamine, cyclooctanone, cyclooctanol, 4-methylcyclohexylamine, 4-methylcyclohexanone, and cis- and trans-4-methylcyclohexanols. The average percent conversions to cyclooctylamine, cyclooctanone, and cyclooctanol were 0.127, 0.08, and 0.092, respectively. The average percent conversions to 4-methylcyclohexylamine and 4-methylcyclohexanone were 0.007 and 0.0013, respectively. No cis- or trans-4-methylcyclohexanol metabolites were found. With cyclooctylsulfamate, 42% was recovered unchanged from the urine. Cyclooctyl- and cycloheptylsulfamates were metabolized to a greater extent than cyclopentylsulfamate, which, in turn, was metabolized to a greater extent than cyclohexylsulfamate (cyclamate) and 4-methylcyclohexylsulfamate.
将非营养性甜味剂环辛基氨基磺酸盐和4-甲基环己基氨基磺酸盐分别喂给雌性Wistar白化大鼠，并检测尿液中可能的代谢产物环辛胺、环辛酮、环辛醇、4-甲基环己胺、4-甲基环己酮以及顺式和反式4-甲基环己醇。环辛胺、环辛酮和环辛醇的平均转化率分别为0.127%、0.08%和0.092%。4-甲基环己胺和4-甲基环己酮的平均转化率分别为0.007%和0.0013%。未发现顺式或反式4-甲基环己醇代谢产物。对于环辛基氨基磺酸盐，42%从尿液中未发生变化地回收。环辛基和环庚基氨基磺酸盐的代谢程度高于环戊基氨基磺酸盐，而环戊基氨基磺酸盐的代谢程度又高于环己基氨基磺酸盐（甜蜜素）和4-甲基环己基氨基磺酸盐。
