Spillane W J, Benson G A
J Pharm Sci. 1978 Feb;67(2):226-8. doi: 10.1002/jps.2600670225.
The nonnutritive sweetener sodium cyclopentylmethyl-sulfamate was fed to Wistar albino rats. The urine was collected for 3 days, combined, and examined (GLC) for the metabolites cyclopentyl-methylamine and cyclopentylmethanol. The percent conversion to these metabolites was 0.077 and 0.0102, respectively. The percent conversion to these to cyclopentylmethylamine was the lowest conversion to amine observed when compared to the metabolism of three other sweet sulfamates, cyclopentylsulfamate, cycloheptylsulfamate, and cyclooctylsulfamate, previously administered to rats. The average excretion of unmetabolized sulfamate was 15.4%. Sodium cyclopentylsulfamate was fed to rats over 9 days, and an analysis was carried out for the metabolites cyclopentylamine, cyclopentanone, and cyclopentanol. A decrease in the level of metabolites occurred after the first 3 days.
将非营养性甜味剂环戊基甲基磺酸钠喂给Wistar白化大鼠。收集尿液3天，合并后用气相色谱法（GLC）检测代谢产物环戊基甲胺和环戊基甲醇。转化为这些代谢产物的百分比分别为0.077和0.0102。与之前给大鼠施用的其他三种甜味氨基磺酸盐（环戊基磺酸盐、环庚基磺酸盐和环辛基磺酸盐）的代谢情况相比，转化为环戊基甲胺的百分比是观察到的向胺转化的最低百分比。未代谢的氨基磺酸盐的平均排泄率为15.4%。将环戊基磺酸钠喂给大鼠9天，并对代谢产物环戊胺、环戊酮和环戊醇进行分析。在最初3天后，代谢产物水平有所下降。
