Benson G A, Spillane W J
J Pharm Sci. 1977 Jun;66(6):881-3. doi: 10.1002/jps.2600660641.
The nonnutritive sweetener cycloheptylsulfamate was administered orally to rabbits and rats. The urine of each species was separately collected for 3 days and examined for the metabolites cycloheptylamine, cycloheptanone, and cycloheptanol and for cycloheptylsulfamate. A previously tested GLC method was adapted for the determination of the metabolites. Cycloheptylsulfamate was assayed by hydrolysis and subsequent measurement of the absorbance of the product formed (lambdamax=489 nm) by the liberated amine with p-benzoquinone. The conversions to the metabolites were 0.276, 0.390, and 0.170%, respectively, in rabbits and 0.064, 0.022, and 0.017%, respectively, in rats.
将非营养性甜味剂环庚基氨基磺酸盐经口给予家兔和大鼠。分别收集每个物种3天的尿液，检测其中的代谢产物环庚胺、环庚酮、环庚醇以及环庚基氨基磺酸盐。采用一种先前经过测试的气相色谱法测定代谢产物。通过水解环庚基氨基磺酸盐并随后测量释放出的胺与对苯醌形成的产物（最大吸收波长=489nm）的吸光度来测定环庚基氨基磺酸盐。在家兔中，转化为代谢产物的比例分别为0.276%、0.390%和0.170%，在大鼠中分别为0.064%、0.022%和0.017%。
