Jiménez-Jiménez F J, Molina J A, Aguilar M V, Meseguer I, Mateos-Vega C J, González-Muñoz M J, de Bustos F, Martínez-Salio A, Ortí-Pareja M, Zurdo M, Martínez-Para M C
Department of Neurology, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid, Spain.
J Neural Transm (Vienna). 1998;105(4-5):497-505. doi: 10.1007/s007020050073.
We compared CSF and serum levels of iron, copper, manganese, and zinc, measured by atomic absorption spectrophotometry, in 37 patients with Parkinson's disease (PD) and 37 matched controls. The CSF levels of zinc were significantly decreased in PD patients as compared with controls (p < 0.05). The serum levels of zinc, and the CSF and serum levels of iron, copper, and manganese, did not differ significantly between PD-patient and control groups. There was no influence of antiparkinsonian therapy on CSF levels of none of these transition metals. These values were not correlated with age, age at onset, duration of the disease, scores of the Unified Parkinson Disease Rating Scale of the Hoehn and Yahr staging in the PD group, with the exception of CSF copper levels with the duration of the disease (r = 0.38, p < 0.05). These results suggest that low CSF zinc concentrations might be related with the risk for PD, although they could be related with oxidative stress processes.
我们采用原子吸收分光光度法，比较了37例帕金森病（PD）患者及37例匹配对照者脑脊液和血清中铁、铜、锰及锌的水平。与对照组相比，PD患者脑脊液锌水平显著降低（p<0.05）。PD患者组与对照组之间，血清锌水平以及脑脊液和血清中铁、铜、锰水平无显著差异。抗帕金森病治疗对这些过渡金属的脑脊液水平均无影响。这些数值与年龄、发病年龄、病程、PD组Hoehn和Yahr分期的统一帕金森病评定量表评分均无相关性，但脑脊液铜水平与病程相关（r=0.38，p<0.05）。这些结果表明，脑脊液锌浓度降低可能与PD风险相关，尽管其可能与氧化应激过程有关。
