Qureshi G A, Qureshi A A, Memon S A, Parvez S H
Medical Research Center, Liaquat University of Medical & Health Sciences, Jamshoro, Pakistan.
J Neural Transm Suppl. 2006(71):229-36. doi: 10.1007/978-3-211-33328-0_24.
We have quantitated CSF and serum levels of Selenium, iron, copper and zinc by Atomic absorption spectrophotometer in 36 patients with parkinson's disease all on L-dopa therapy. Out of these 19 showed on or positive response to L-dopa where as 21 patients showed on and off response. These data were compared with 21 healthy controls. The results showed that serum levels of iron, copper and zinc remained unchanged where as in CSF, significant decrease in zinc was found in both on and on/off PD patients indicating the deficiency of zinc which continues in the worsening clinical condition of off patients. The level of copper remained unchanged in both on and on/off PD patients. Iron and selenium increase in CSF of both patients which is a clear evidence of relationship between increased iron and selenium level in brain which could be correlated with decrease in dopamine levels and oxidative stress in PD Patients.
我们使用原子吸收分光光度计对36例均接受左旋多巴治疗的帕金森病患者的脑脊液和血清中的硒、铁、铜和锌水平进行了定量分析。其中19例对左旋多巴表现出持续或阳性反应，而21例患者表现出开关反应。这些数据与21名健康对照者进行了比较。结果显示，血清中的铁、铜和锌水平保持不变，而在脑脊液中，持续和开关型帕金森病患者的锌均显著降低，这表明锌缺乏在开关型患者病情恶化时仍持续存在。持续和开关型帕金森病患者的铜水平均保持不变。两组患者脑脊液中的铁和硒均增加，这清楚地证明了大脑中铁和硒水平升高之间的关系，这可能与帕金森病患者多巴胺水平降低和氧化应激有关。
