Clark S, Campbell F, Moore T, Jayson M I, King T A, Herrick A L
Rheumatic Diseases Centre, Hope Hospital, Salford, M6 8HD, United Kingdom.
Microvasc Res. 1999 May;57(3):284-91. doi: 10.1006/mvre.1998.2124.
This was a pilot study to investigate the new technique of laser Doppler imaging (scanning laser Doppler) as a tool to quantify microvascular blood flow in the digits of patients with primary Raynaud's phenomenon (PRP) and systemic sclerosis (SSc), and to determine in the first instance whether the flux patterns obtained differ between patients with SSc, patients with PRP, and healthy control subjects. Laser Doppler images of the dorsum of the hand and fingers were acquired at 23 and 30 degrees C in 17 healthy control subjects, 7 patients with PRP, 9 patients with the diffuse cutaneous variant of SSc, and 24 patients with the limited cutaneous variant of SSc. Different flux parameters were compared between groups. Analysis of variance found significant differences between groups in two tests: maximum difference in flux between fingertips of the same hand at 23 degrees C (P = 0.001) and maximum gradient in flux along a finger ("distal-dorsal" flux difference) at 30 degrees C (P = 0. 019). Post hoc tests highlighted the differences between controls and patients with limited cutaneous SSc. This pilot study suggests that laser Doppler imaging may allow objective measurement of microvascular flow in patients with PRP and SSc. This new technique may overcome many of the problems inherent in single-channel laser Doppler equipment.
这是一项初步研究，旨在探讨激光多普勒成像新技术（扫描激光多普勒）作为一种工具，用于量化原发性雷诺现象（PRP）和系统性硬化症（SSc）患者手指的微血管血流，并首先确定SSc患者、PRP患者和健康对照者所获得的通量模式是否存在差异。在17名健康对照者、7名PRP患者、9名弥漫性皮肤型SSc患者和24名局限性皮肤型SSc患者中，于23摄氏度和30摄氏度获取手背和手指的激光多普勒图像。比较了各组之间不同的通量参数。方差分析发现在两项测试中各组之间存在显著差异：23摄氏度时同一只手的指尖之间的最大通量差异（P = 0.001）以及30摄氏度时沿手指的通量最大梯度（“远端 - 背侧”通量差异）（P = 0.019）。事后检验突出了对照组与局限性皮肤型SSc患者之间的差异。这项初步研究表明，激光多普勒成像可能允许对PRP和SSc患者的微血管血流进行客观测量。这项新技术可能克服单通道激光多普勒设备固有的许多问题。
