Picart C, Carpentier P H, Brasseur S, Galliard H, Piau J M
Laboratoire de Médecine Vasculaire, Université Joseph Fourier, Centre Hospitalier Universitaire, Grenoble, France.
Clin Hemorheol Microcirc. 1998 Apr;18(1):47-58.
A combined study of microcirculation hemodynamics in vivo and blood rheometry has been carried out in patients with scleroderma compared to primary Raynaud's phenomenon (PRP) and healthy controls (HC). Laser Doppler perfusion imaging was used to assess superficial skin blood flow in the fingers before, during and after local cold exposure. Blood viscosity was measured at 19 and 37 degrees C. Dynamic and transient flows were also investigated. The scleroderma group showed a significantly lower level of perfusion before the cold test, that was further decreased during and after cold exposure, the difference with PRP being maximal during the rewarming period. It also showed a significantly increased viscosity (p < 0.05) at low shear rates. Hemorheological behavior of the PRP group was similar to the HC group. A significant negative correlation between the LDI perfusion and the apparent blood viscosity at low shear rates was found for the whole population. These findings suggest that rheological factors may be involved in the abnormal cold reactivity of patients with scleroderma.
与原发性雷诺现象（PRP）患者及健康对照者（HC）相比，对硬皮病患者进行了体内微循环血流动力学与血液流变学的联合研究。采用激光多普勒灌注成像技术评估手指在局部冷暴露前、暴露期间及暴露后的浅表皮肤血流。在19摄氏度和37摄氏度下测量血液粘度。还研究了动态和瞬态血流。硬皮病组在冷试验前的灌注水平显著较低，在冷暴露期间及之后进一步降低，与PRP组的差异在复温期最大。该组在低剪切速率下还显示出血粘度显著增加（p<0.05）。PRP组的血液流变学行为与HC组相似。在整个人群中，发现低剪切速率下激光多普勒成像（LDI）灌注与表观血液粘度之间存在显著负相关。这些发现表明，流变学因素可能与硬皮病患者异常的冷反应性有关。
