Golomb H M, Lindgren V, Rowley J D
Virchows Arch B Cell Pathol. 1978 Nov 17;29(1-2):113-20. doi: 10.1007/BF02899344.
We studied the chromosomes from 26 patients with hairy cell leukemia (HCL) to ascertain the frequency and types of consistent chromosomal abnormalities. Samples from 21 patients were obtained from peripheral blood cultures grown 24 and 48 h without phytohemagglutinin, or from bone marrow samples. Two male patients had similar, consistent abnormalities; one patient's karyotype was 46, X, +12; that of the second was 46, X, +C marker. In the latter case, the distal long arm of the C marker most closely resembled chromosome No. 12 from band q14 to q terminal, but the short arm and proximal long arm were of undetermined origin. Both karyotypes lacked the Y chromosome. Nine of the 21 patients had abnormalities in single cells. One patient had, in one sample, a single abnormal cell with an extra No. 3 and an extra No. 12 (48, XY, +3, +12), and in a later sample, a second cell of poor morphology which also could have been trisomic for No. 12. Another patient had one cell with an unusually bright short arm, as well as two cells, with different abnormalities, both involving the short arm of chromosome No. 1. The two patients with consistent chromosome abnormalities had rapidly progressive disease in spite of splenectomy, and their clinical course from the time of diagnosis was relatively short (5 and 7 months, respectively).
我们研究了26例毛细胞白血病（HCL）患者的染色体，以确定一致的染色体异常的频率和类型。21例患者的样本取自未添加植物血凝素培养24小时和48小时的外周血培养物，或取自骨髓样本。两名男性患者有相似的、一致的异常；一名患者的核型为46,X,+12；另一名患者的核型为46,X,+C标记。在后一种情况下，C标记的远端长臂与12号染色体从q14带至q末端最为相似，但短臂和近端长臂来源不明。两种核型均缺乏Y染色体。21例患者中有9例存在单细胞异常。一名患者在一个样本中有一个异常细胞，额外有一条3号染色体和一条12号染色体（48,XY,+3,+12），在后来的样本中有一个形态不佳的细胞，也可能是12号染色体三体。另一名患者有一个短臂异常明亮的细胞，以及两个有不同异常的细胞，均涉及1号染色体短臂。两名有一致染色体异常的患者尽管接受了脾切除术，但疾病进展迅速，从诊断时起他们的临床病程相对较短（分别为5个月和7个月）。
