市售猫杯状病毒（FCV）疫苗免疫血清对FCV野毒株的中和特性。

Neutralizing feature of commercially available feline calicivirus (FCV) vaccine immune sera against FCV field isolates.

作者信息

Hohdatsu T, Sato K, Tajima T, Koyama H

机构信息

Department of Veterinary Infectious Diseases, School of Veterinary Medicine and Animal Sciences, Kitasato University, Aomori, Japan.

出版信息

J Vet Med Sci. 1999 Mar;61(3):299-301. doi: 10.1292/jvms.61.299.

DOI:10.1292/jvms.61.299

PMID:10331208

Abstract

Four types of commercially available feline calicivirus (FCV) vaccine were compared in terms of their efficacy on the basis of the ability of the sera of specific-pathogen-free cats immunized by two injections of each type of vaccine to neutralize FCV field isolates. Each vaccine immune serum neutralized relatively well strains F4, F9, and 255, which were FCV laboratory strains. As to 36 strains of field isolates, however, vaccines A, B, C, and D immune sera did not neutralize 18-20 of the strains (50.0%-55.6%), 19-22 of the strains (52.8%-61.1%), 22-25 of the strains (61.1%-69.4%), and 8-16 of the strains (22.2%-44.4%), respectively. These results indicate that there is much difference in neutralizing antigenicity between the existing vaccine strains and the FCV strains that are prevalent in Japan, suggesting the need for improvement of FCV vaccines.

摘要

对四种市售猫杯状病毒（FCV）疫苗进行了比较，比较依据是每种疫苗经两次注射免疫特定病原体-free猫后血清中和FCV野外分离株的能力。每种疫苗免疫血清对FCV实验室菌株F4、F9和255的中和效果相对较好。然而，对于36株野外分离株，疫苗A、B、C和D免疫血清分别不能中和18 - 20株（50.0% - 55.6%）、19 - 22株（52.8% - 61.1%）、22 - 25株（61.1% - 69.4%）和8 - 16株（22.2% - 44.4%）。这些结果表明，现有疫苗株与日本流行的FCV株之间在中和抗原性方面存在很大差异，提示需要改进FCV疫苗。