Pedersen N C, Hawkins K F
Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis 95616, USA.
Vet Microbiol. 1995 Nov;47(1-2):141-56. doi: 10.1016/0378-1135(95)00101-f.
The study was concerned with possible reasons for the persistence of both acute and chronic feline calicivirus (FCV)-induced disease and sustained oral carriage in the field in the face of routine FCV immunization. It was concluded from this study that: 1) the original FCV-F9 strain, which is the basis of most live vaccines, still generates cross-reactive antibodies against almost all field strains in California, 2) vaccine strains derived from FCV-F9 may not be as broadly cross-protective as the parent strain, 3) whole inactivated FCV-2280 vaccine evokes high virus neutralizing antibody titers with an equally broad spectrum of cross-reactivity as FCV-F9, 4) all vaccine strains of FCV cause acute disease signs and protracted oral shedding when administered orally, 5) strains isolated from the mouth five to ten weeks following oral inoculation can differ from parental virus, usually appearing more vaccine resistant, 6) cats previously infected with field or vaccine strains develop much less severe acute illness when subsequently infected with heterologous FCV strains but are not protected against the chronic carrier state. Therefore, the persistence of FCV in the field cannot be explained solely by the emergence of vaccine resistant strains and vaccine virus itself may contribute to both acute and chronic infection and disease.
该研究关注的是，在常规接种猫杯状病毒（FCV）疫苗的情况下，急性和慢性FCV诱导的疾病持续存在以及在野外持续口腔携带病毒的可能原因。从这项研究得出的结论是：1）作为大多数活疫苗基础的原始FCV - F9毒株，仍能产生针对加利福尼亚几乎所有野外毒株的交叉反应抗体；2）源自FCV - F9的疫苗毒株可能不像亲本毒株那样具有广泛的交叉保护作用；3）全灭活FCV - 2280疫苗能引发高病毒中和抗体滴度，且具有与FCV - F9同样广泛的交叉反应谱；4）所有FCV疫苗毒株经口服接种后都会引起急性疾病症状和长期口腔排毒；5）口服接种后五到十周从口腔分离出的毒株可能与亲本病毒不同，通常表现出更强的疫苗抗性；6）先前感染过野外毒株或疫苗毒株的猫在随后感染异源FCV毒株时，急性疾病的严重程度会低得多，但不能预防慢性携带状态。因此，FCV在野外的持续存在不能仅用疫苗抗性毒株的出现来解释，疫苗病毒本身可能导致急性和慢性感染及疾病。
