与单株猫杯状病毒疫苗相比，双株猫杯状病毒疫苗能刺激产生更广泛的交叉中和抗体，并且当用与烈性全身性疾病相关的同源猫杯状病毒毒株攻击时，可减轻接种疫苗猫的临床症状。
A dual-strain feline calicivirus vaccine stimulates broader cross-neutralization antibodies than a single-strain vaccine and lessens clinical signs in vaccinated cats when challenged with a homologous feline calicivirus strain associated with virulent systemic disease.
作者信息
Huang Chengjin, Hess Jennifer, Gill Michael, Hustead David
机构信息
Fort Dodge Animal Health, 9225 Indian Creek Parkway, Suite 400, Overland Park, KS 66213, USA.
出版信息
J Feline Med Surg. 2010 Feb;12(2):129-37. doi: 10.1016/j.jfms.2009.08.006.
Abstract
Feline calicivirus (FCV) causes an array of clinical disease in cats. Traditionally this disease has been associated with respiratory disease, limping, or chronic stomatitis. Within the last 10 years, virulent systemic feline calicivirus (VS-FCV) has been recognized which causes additional clinical signs and has a higher fatality rate. A dual-strain FCV vaccine containing a strain of FCV associated with traditional respiratory disease and a VS-FCV strain stimulates serum cross-neutralization antibodies when tested against field strains from Europe and VS-FCV strains from USA. Following challenge with a homologous VS-FCV strain, vaccinated cats had significantly reduced clinical signs.
摘要
猫杯状病毒（FCV）可引发猫的一系列临床疾病。传统上，这种疾病与呼吸道疾病、跛行或慢性口腔炎有关。在过去10年中，已确认存在强毒性全身性猫杯状病毒（VS-FCV），它会引发更多临床症状且致死率更高。一种双毒株FCV疫苗，包含一株与传统呼吸道疾病相关的FCV毒株和一株VS-FCV毒株，在针对来自欧洲的野外毒株和来自美国的VS-FCV毒株进行测试时，能刺激产生血清交叉中和抗体。在用同源VS-FCV毒株进行攻毒后，接种疫苗的猫的临床症状显著减轻。
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