Levine J S, Koh J S, Subang R, Rauch J
Renal Section, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA.
Exp Mol Pathol. 1999 Apr;66(1):82-98. doi: 10.1006/exmp.1999.2243.
Apoptotic cell antigens have been increasingly recognized as the targets of autoantibodies across a broad spectrum of autoimmune diseases, including systemic lupus erythematosus (SLE) and the antiphospholipid (aPL) syndrome. In this review, we will focus on one set of apoptotic antigens, namely, those targeted in the aPL syndrome. Here we discuss the biology of aPL autoantibodies and recent work from our and other laboratories demonstrating that apoptotic cells express unique antigen(s) that serve(s) as both immunogen and antigen for aPL autoantibodies. Specific features or events occurring at the surface of apoptotic cells, which may influence immunogenicity and/or antigenicity, will also be discussed. Finally, we will speculate on the broader implications of these findings for the development of systemic autoimmunity as seen in SLE.
凋亡细胞抗原已日益被认为是包括系统性红斑狼疮（SLE）和抗磷脂（aPL）综合征在内的广泛自身免疫性疾病中自身抗体的靶标。在本综述中，我们将聚焦于一组凋亡抗原，即那些在aPL综合征中成为靶标的抗原。在此，我们讨论aPL自身抗体的生物学特性，以及我们实验室和其他实验室的最新研究成果，这些研究表明凋亡细胞表达独特的抗原，这些抗原既是aPL自身抗体的免疫原又是抗原。我们还将讨论凋亡细胞表面发生的可能影响免疫原性和/或抗原性的特定特征或事件。最后，我们将推测这些发现对SLE中所见系统性自身免疫病发展的更广泛影响。
