Kerins G M, MacNicoll A D
Central Science Laboratory, Ministry of Agriculture, Fisheries and Food, Sand Hutton, York, UK.
Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1999 Mar;122(3):307-16. doi: 10.1016/s0742-8413(98)10128-7.
The half-lives and regeneration rates of clotting factors II, VII, and X in the plasma of anticoagulant-resistant and susceptible rats were determined. There is little or no difference in the half-lives of factors II and X in anticoagulant-resistant rats compared to susceptible rats, but the half-life of factor VII is longer in anticoagulant-resistant rats. In anticoagulant-resistant rats critical clotting factors appear to be carboxylated in preference to factor II, whereas the opposite occurs in susceptible rats; this may contribute to an animal's resistance status.
测定了抗凝血大鼠和敏感大鼠血浆中凝血因子II、VII和X的半衰期及再生率。与敏感大鼠相比，抗凝血大鼠中凝血因子II和X的半衰期几乎没有差异或无差异，但抗凝血大鼠中凝血因子VII的半衰期更长。在抗凝血大鼠中，关键凝血因子似乎优先于凝血因子II发生羧化，而在敏感大鼠中情况则相反；这可能有助于动物的抗凝血状态。
