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脐血中的生长调节素:与胎龄和出生体重的关系。

Somatomedin in cord blood: relationship to gestational age and birth size.

作者信息

Gluckman P D, Brinsmead M W

出版信息

J Clin Endocrinol Metab. 1976 Dec;43(6):1378-81. doi: 10.1210/jcem-43-6-1378.

DOI:10.1210/jcem-43-6-1378
PMID:1033949
Abstract

Somatomedin (SM) was determined by bioassay in cord blood from 100 neonates born at 24-42 weeks of gestation and from three infants with major congenital malformations. SM levels rose with gestational age and had a positive correlation with birth weight, length and head circumference independantly of gestational age. These findings suggest a relationship between somatomedin and fetal growth.

摘要

采用生物测定法测定了100例孕24 - 42周出生的新生儿及3例患有严重先天性畸形婴儿的脐血中生长调节素(SM)的含量。生长调节素水平随孕周增加而升高,且与出生体重、身长和头围呈正相关,不受孕周影响。这些发现提示生长调节素与胎儿生长之间存在关联。

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Somatomedin in cord blood: relationship to gestational age and birth size.脐血中的生长调节素:与胎龄和出生体重的关系。
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引用本文的文献

1
Maternal-placental-fetal interactions in the endocrine regulation of fetal growth: role of somatotrophic axes.母婴-胎盘-胎儿相互作用在胎儿生长内分泌调节中的作用:生长激素轴的作用
Endocrine. 2002 Oct;19(1):81-9. doi: 10.1385/ENDO:19:1:81.
2
Size at birth and plasma insulin-like growth factor-1 concentrations.出生时的体重与血浆胰岛素样生长因子-1浓度。
Arch Dis Child. 1995 Oct;73(4):287-93. doi: 10.1136/adc.73.4.287.
3
Increased somatomedin and cartilage metabolic activity in rabbit fetuses injected with insulin in utero.子宫内注射胰岛素的兔胎儿中生长介素增加及软骨代谢活性增强。
Diabetologia. 1980 Aug;19(2):143-7. doi: 10.1007/BF00421861.
4
Human fetal cartilage response to plasma somatomedin activity in relation to gestational age.人类胎儿软骨对血浆生长调节素活性的反应与胎龄的关系。
Calcif Tissue Int. 1981;33(3):205-9. doi: 10.1007/BF02409439.
5
Synthesis of somatomedin C/insulin-like growth factor I by human placenta.人胎盘合成生长调节素C/胰岛素样生长因子I。
Mol Biol Rep. 1986;11(4):231-6. doi: 10.1007/BF00419602.