Ashton I K, Phizackerley S
Calcif Tissue Int. 1981;33(3):205-9. doi: 10.1007/BF02409439.
The response of human fetal costal cartilage (gestational age 12--25 weeks) to plasma containing somatomedin activity has been examined in vitro. Uptake of both 3H-thymidine and 35S-sulfate into the cartilage was increased; the increase in 35S-sulfate uptake was relatively constant (mean = 198% of basal, N = 25) throughout the period studied; however, the increase in 3H-thymidine uptake varied with gestational age, reaching a maximum of about 200% at 15--17 weeks and decreasing thereafter. Such a change in cartilage sensitivity to somatomedins could be an important feature in the pattern of skeletal growth of the human fetus during gestation. The data do not confirm that human cartilage is most sensitive to somatomedins during intrauterine life.
已在体外研究了人胎儿肋软骨（孕龄12 - 25周）对含有生长调节素活性的血浆的反应。软骨对3H-胸腺嘧啶核苷和35S-硫酸盐的摄取均增加；在整个研究期间，35S-硫酸盐摄取的增加相对恒定（平均值为基础值的198%，N = 25）；然而，3H-胸腺嘧啶核苷摄取的增加随孕龄而变化，在15 - 17周时达到最大值约200%，此后下降。软骨对生长调节素敏感性的这种变化可能是人类胎儿在妊娠期骨骼生长模式中的一个重要特征。这些数据并未证实人软骨在子宫内生活期间对生长调节素最为敏感。
