慢性丙型肝炎患者泪液乳铁蛋白浓度降低。
Decreased tear lactoferrin concentration in patients with chronic hepatitis C.
作者信息
Abe T, Nakajima A, Matsunaga M, Sakuragi S, Komatsu M
机构信息
Department of Ophthalmology, Akita University School of Medicine, Akita City, Japan.
出版信息
Br J Ophthalmol. 1999 Jun;83(6):684-7. doi: 10.1136/bjo.83.6.684.
BACKGROUND/AIMS: Decreased tear volume in patients with chronic hepatitis C has been reported in the literature. Lactoferrin is abundantly present in human tears, the main source of which is the acini of the lacrimal glands. In this study tear lactoferrin levels were measured to investigate the dry eye condition of patients with chronic hepatitis C.
METHODS
Lactoferrin in tears/fluid was measured by a radial immunodiffusion assay in 42 patients with chronic hepatitis C. The rate of lacrimal secretion was determined by the cotton thread test. Rose bengal staining of the ocular surface was also performed.
RESULTS
Only three patients out of 42 complained of dry eye sensation and, in 31 patients, six showed positive results on the rose bengal staining test of the ocular surface. The lactoferrin concentration of tear fluid in the chronic hepatitis C group (1.42 (SD 0.56) mg/ml) was significantly lower than in the control group (1.90 (0.62) mg/ml; p <0.00048). The cotton thread test results in the chronic hepatitis C group (12.9 (5. 5) mm) were significantly lower than in the control group (17.9 (5. 3) mm; p<0.00048). Also, in the chronic hepatitis C group, tear lactoferrin concentration correlated with the results of the cotton thread test (r = 0.35, p<0.05).
CONCLUSION
Chronic hepatitis C patients showed both decreased tear volume, and decreased tear lactoferrin concentration. These findings suggest that there may be dysfunction of the lacrimal glands in patients with chronic hepatitis C, which may account for the mild dry eye.
背景/目的：文献报道慢性丙型肝炎患者泪液量减少。乳铁蛋白大量存在于人类泪液中，其主要来源是泪腺腺泡。本研究通过测量泪液乳铁蛋白水平来调查慢性丙型肝炎患者的干眼状况。
方法
采用放射免疫扩散法测量42例慢性丙型肝炎患者泪液/眼液中的乳铁蛋白。通过棉线试验测定泪液分泌率。还对眼表进行了孟加拉玫瑰红染色。
结果
42例患者中只有3例主诉有干眼感觉，31例患者中有6例眼表孟加拉玫瑰红染色试验呈阳性。慢性丙型肝炎组泪液乳铁蛋白浓度（1.42（标准差0.56）mg/ml）显著低于对照组（1.90（0.62）mg/ml；p<0.00048）。慢性丙型肝炎组棉线试验结果（12.9（5.5）mm）显著低于对照组（17.9（5.3）mm；p<0.00048）。此外，在慢性丙型肝炎组中，泪液乳铁蛋白浓度与棉线试验结果相关（r = 0.35，p<0.05）。
结论
慢性丙型肝炎患者泪液量和泪液乳铁蛋白浓度均降低。这些发现表明慢性丙型肝炎患者可能存在泪腺功能障碍，这可能是导致轻度干眼的原因。
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