轻度涎腺炎：丙型肝炎病毒感染患者的常见表现。

Mild sialoadenitis: a common finding in patients with hepatitis C virus infection.

作者信息

Pirisi M, Scott C, Fabris C, Ferraccioli G, Soardo G, Ricci R, Toniutto P, Avellini C, Vitulli D, Miotti A M

机构信息

Dept. of Internal Medicine, University of Udine, Italy.

出版信息

Scand J Gastroenterol. 1994 Oct;29(10):940-2. doi: 10.3109/00365529409094867.

DOI:10.3109/00365529409094867

PMID:7839102

Abstract

BACKGROUND

Sjögren's syndrome (SS) is an autoimmune disease of presumed viral origin; sialoadenitis has been reported to occur in hepatitis C virus (HCV) infection.

METHODS

Lip biopsy specimens were graded in 32 consecutive patients with either HCV-related chronic liver disease or SS.

RESULTS

Seventeen of 22 HCV-positive patients had sialoadenitis, although generally mild (15 of 17, grades I-II). Severe inflammation (grades III-IV) was observed in 8 of 10 patients with SS (chi-square = 12.6; P < 0.0005). Moreover, HCV-positive patients with sialoadenitis differed from patients with SS in female sex prevalence (6 of 17 versus 10 of 10; chi-square = 10.9; P = 0.0001) and presence of serum antinuclear autoantibodies (0 of 17 versus 9 of 10; chi-square = 23.0; P < 0.0001). Five of 13 HCV-positive patients and 7 of 8 patients with SS were HLA-DR3-positive (chi-square = 4.9; P < 0.05).

CONCLUSIONS

Sialoadenitis of HCV-related liver disease is common but differs from SS with regard to predisposing genetic factors, expression of autoimmune markers, and histopathologic severity.

摘要

背景

干燥综合征（SS）是一种推测起源于病毒的自身免疫性疾病；据报道，丙型肝炎病毒（HCV）感染可发生涎腺炎。

方法

对32例患有HCV相关慢性肝病或SS的连续患者的唇活检标本进行分级。

结果

22例HCV阳性患者中有17例患有涎腺炎，尽管通常较轻（17例中有15例为I-II级）。10例SS患者中有8例观察到严重炎症（III-IV级）（卡方检验=12.6；P<0.0005）。此外，患有涎腺炎的HCV阳性患者与SS患者在女性患病率（17例中有6例与10例中有10例；卡方检验=10.9；P=0.0001）和血清抗核自身抗体的存在情况（17例中有0例与10例中有9例；卡方检验=23.0；P<0.0001）方面存在差异。13例HCV阳性患者中有5例以及8例SS患者中有7例为HLA-DR3阳性（卡方检验=4.9；P<0.05）。