Band G P, van Boxtel G J
Faculty of Psychology, University of Amsterdam, The Netherlands.
Acta Psychol (Amst). 1999 Apr;101(2-3):179-211. doi: 10.1016/s0001-6918(99)00005-0.
What is the neurophysiological locus of inhibition when preparation for a manual response is countermanded? This paper evaluates data and models that pertain to inhibitory mechanisms operating in stop paradigms. In a model of De Jong, Coles and Logan (1995), (Strategies and mechanisms in nonselective and selective inhibitory motor control. Journal of Experimental Psychology: Human Perception and Performance, 21, 3, 498-511), a mechanism for nonselective inhibition operates peripheral to the motor cortex, while a selective mechanism operates at a central cortical level. We argue, however, that a peripheral mechanism of inhibition is incorrectly inferred from inhibition data available to date. Neurophysiological and psychophysiological data suggest that inhibitory processes always involve the cortex, and inhibitory effects are exerted upstream from the primary motor cortex. The prefrontal cortex and basal ganglia are candidate agents of response inhibition, whereas possible sites of inhibition are the thalamus and motor cortex.
当手动反应的准备被取消时，抑制作用的神经生理位点是什么？本文评估了与停止范式中运行的抑制机制相关的数据和模型。在德容、科尔斯和洛根（1995年）的一个模型中（《非选择性和选择性抑制性运动控制的策略和机制》。《实验心理学杂志：人类感知与表现》，21卷，第3期，498 - 511页），一种非选择性抑制机制在运动皮层外周起作用，而一种选择性机制在中央皮层水平起作用。然而，我们认为，从目前可用的抑制数据中错误地推断出了一种外周抑制机制。神经生理学和心理生理学数据表明，抑制过程总是涉及皮层，并且抑制作用在初级运动皮层的上游发挥。前额叶皮层和基底神经节是反应抑制的候选因素，而可能的抑制位点是丘脑和运动皮层。
