Belley A, Keller K, Göttke M, Chadee K
Institute of Parasitology, McGill University, Ste. Anne de Bellevue, Quebec, Canada.
Am J Trop Med Hyg. 1999 Apr;60(4 Suppl):10-5. doi: 10.4269/ajtmh.1999.60.10.
Intestinal mucins are key components of the first line of host defense against intestinal pathogens. These large glycoconjugates secreted by specialized exocrine goblet cells form viscous gels that trap microorganisms and irritants and limit their diffusion to the intestinal epithelium. Moreover, they allow for colonization by indigenous bacterial flora that prevents attachment of pathogenic microbes. The interaction between microbes and mucins involves mucin carbohydrate side chains and microbial adhesin molecules. Certain microorganisms and disease states may alter mucin biochemistry or expression. Although these alterations most likely contribute to disease processes, the full impact of these phenomena are still unclear. The development of mucin-secreting cell lines has facilitated the study of mucin biology and aided our understanding of mucin-microbial interactions.
肠道黏蛋白是宿主抵御肠道病原体第一道防线的关键组成部分。这些由特殊的外分泌杯状细胞分泌的大型糖缀合物形成黏性凝胶，可捕获微生物和刺激物，并限制它们向肠上皮扩散。此外，它们还允许本土细菌菌群定植，从而防止致病微生物附着。微生物与黏蛋白之间的相互作用涉及黏蛋白碳水化合物侧链和微生物黏附分子。某些微生物和疾病状态可能会改变黏蛋白的生物化学性质或表达。尽管这些改变很可能促成疾病进程，但这些现象的全面影响仍不清楚。分泌黏蛋白细胞系的发展促进了黏蛋白生物学的研究，并有助于我们理解黏蛋白与微生物的相互作用。
