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急迫性尿失禁。生活质量与患者对症状减轻的评估。

Urge incontinence. Quality of life and patients' valuation of symptom reduction.

作者信息

O'Conor R M, Johannesson M, Hass S L, Kobelt-Nguyen G

机构信息

Centre for Health Economics, Stockholm School of Economics, Sweden.

出版信息

Pharmacoeconomics. 1998 Nov;14(5):531-9. doi: 10.2165/00019053-199814050-00005.

Abstract

OBJECTIVE

Previous studies have demonstrated the effect of incontinence, and urge incontinence in particular, on patients' quality of life. This study assessed the effects of urge incontinence on quality of life and measured the value of a reduction in symptoms.

DESIGN

A self-administered questionnaire was mailed to 591 patients with urge or mixed incontinence. 495 (83.8%) surveys were returned with complete quality of life and symptom data. Of the total sample, 411 patients received the willingness-to-pay (WTP) survey, from which 257 (62.53%) returns were judged complete and reliable. Information was collected about the number of micturitions and urinary leakages. Health-related quality of life (HR-QOL) was measured using the Short Form 36 (SF-36) Health Survey. Socioeconomic characteristics were also recorded. Value was assessed with a binary WTP question.

MAIN OUTCOME MEASURES AND RESULTS

Quality of life among the sample population was significantly lower in 5 of 8 dimensions compared with the general US population, and was significantly related to the severity of the symptoms in 6 of 8 dimensions. The median (mean) willingness to pay was $US27.24 ($US87.74) per month for a 25% reduction in micturitions and leakages, and $US75.92 ($US244.54) per month for a 50% reduction in micturitions and leakages. As expected, the willingness to pay was significantly related to the size of the reduction in micturitions and leakages, and household income.

CONCLUSIONS

Patients with incontinence perceive substantial benefits from a reduction in the number of micturitions and leakages.

摘要

目的

既往研究已证实尿失禁,尤其是急迫性尿失禁对患者生活质量的影响。本研究评估了急迫性尿失禁对生活质量的影响,并衡量了症状减轻的价值。

设计

向591例急迫性或混合性尿失禁患者邮寄了一份自填式问卷。495份(83.8%)问卷被收回,包含完整的生活质量和症状数据。在总样本中,411例患者接受了支付意愿(WTP)调查,其中257份(62.53%)回复被判定为完整且可靠。收集了排尿次数和漏尿次数的信息。使用简短健康调查问卷36项(SF-36)测量健康相关生活质量(HR-QOL)。还记录了社会经济特征。通过一个二元WTP问题评估价值。

主要结局指标及结果

与美国普通人群相比,样本人群在8个维度中的5个维度上生活质量显著更低,且在8个维度中的6个维度上与症状严重程度显著相关。排尿次数和漏尿次数减少25%时,每月支付意愿中位数(均值)为27.24美元(87.74美元);排尿次数和漏尿次数减少50%时,每月支付意愿中位数(均值)为75.92美元(244.54美元)。正如预期的那样,支付意愿与排尿次数和漏尿次数的减少幅度以及家庭收入显著相关。

结论

尿失禁患者认为排尿次数和漏尿次数减少能带来显著益处。

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