Matsumoto N, Tsuchida T, Nakamura H, Sawa R, Takahashi Y, Naganawa H, Iinuma H, Sawa T, Takeuchi T, Shiro M
Institute of Microbial Chemistry, Tokyo, Japan.
J Antibiot (Tokyo). 1999 Mar;52(3):276-80. doi: 10.7164/antibiotics.52.276.
The absolute structure of a new antibiotic lactonamycin is described. The NMR studies deduced one of four possible structures for the aglycon attached by a rhodinose through glycosidic bond. The stereochemistry of the sugar obtained by an acid hydrolysis was determined to be L-form by measuring optical rotation. The stereochemistry of the aglycon was determined by X-ray crystallographic analysis.
描述了一种新型抗生素内酯霉素的绝对结构。核磁共振研究推断出通过鼠李糖以糖苷键连接的苷元四种可能结构中的一种。通过测量旋光性确定酸水解得到的糖的立体化学为L型。苷元的立体化学通过X射线晶体学分析确定。
