尼沙霉素，一种来自链霉菌属K106的新型马尼霉素类抗生素。II. 结构测定及构效关系
Nisamycin, a new manumycin group antibiotic from Streptomyces sp. K106. II. Structure determination and structure-activity relationships.
作者信息
Hayashi K, Nakagawa M, Fujita T, Tanimori S, Nakayama M
机构信息
Department of Agricultural Chemistry, Faculty of Agriculture, University of Osaka Prefecture, Japan.
出版信息
J Antibiot (Tokyo). 1994 Oct;47(10):1110-5. doi: 10.7164/antibiotics.47.1110.
Nisamycin, a novel manumycin group antibiotic, was isolated from the culture broth of Streptomyces sp. K106. Structural elucidation of nisamycin was achieved by detailed NMR spectral analyses and comparison of the NMR data of nisamycin with those of other manumycin group antibiotics. The structure was confirmed by chromic acid oxidation. The absolute stereochemistry of nisamycin was determined to be 4R, 5S and 6R from the CD spectra of nisamycin and chromic oxidation of nisamycin. In addition, some structure activity-relationships were examined.
尼沙霉素是一种新型的马尼霉素类抗生素，从链霉菌属K106的发酵液中分离得到。通过详细的核磁共振光谱分析以及将尼沙霉素的核磁共振数据与其他马尼霉素类抗生素的数据进行比较，确定了尼沙霉素的结构。通过铬酸氧化对结构进行了确认。根据尼沙霉素的圆二色光谱和尼沙霉素的铬酸氧化反应，确定了尼沙霉素的绝对立体化学构型为4R、5S和6R。此外，还研究了一些构效关系。
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