Sawa R, Takahashi Y, Nakamura H, Nakamura K T, Naganawa H, Takeuchi T
Institute of Microbial Chemistry, Tokyo, Japan.
J Antibiot (Tokyo). 1994 Nov;47(11):1280-3. doi: 10.7164/antibiotics.47.1280.
The planar structure of aldecalmycin (1) had been determined in the previous paper, together with the conformations of the substituted trans decalin ring having one double bond and the sugar: beta-glucopyranoside type. The absolute configuration of 1 was a following problem to be solved. X-Ray crystallographic analysis of crystalline 4'-6'-O-benzylidenedihydroaldecalmycin (4) revealed the relative configuration. On the other hand, the stereoisomerism of the sugar was determined to be D by the optical rotation value of tetra-O-acetyl-alpha-methylglucopyranoside derived from 1. These results established the absolute configuration of 1.
醛卡霉素（1）的平面结构已在之前的论文中确定，同时还确定了具有一个双键的取代反式十氢萘环和糖（β-D-吡喃葡萄糖苷型）的构象。1的绝对构型是接下来需要解决的问题。对结晶的4'-6'-O-亚苄基二氢醛卡霉素（4）进行X射线晶体学分析揭示了其相对构型。另一方面，通过由1衍生得到的四-O-乙酰-α-甲基吡喃葡萄糖苷的旋光值确定糖的立体异构为D型。这些结果确定了1的绝对构型。
