肌萎缩侧索硬化症患者血清中β-胡萝卜素、α-胡萝卜素和维生素A的水平

Serum levels of beta-carotene, alpha-carotene, and vitamin A in patients with amyotrophic lateral sclerosis.

作者信息

Molina J A, de Bustos F, Jiménez-Jiménez F J, Esteban J, Guerrero-Sola A, Zurdo M, Ortí-Pareja M, Gasalla T, Gómez-Escalonilla C, Ramírez-Ramos C, Guillamón F, Arenas J

机构信息

Department of Neurology, Hospital Universitario Doce de Octubre, Madrid, Spain.

出版信息

Acta Neurol Scand. 1999 May;99(5):315-7. doi: 10.1111/j.1600-0404.1999.tb00682.x.

DOI:10.1111/j.1600-0404.1999.tb00682.x

PMID:10348162

Abstract

To elucidate whether serum alpha and beta-carotene and retinol levels are related with the risk for amyotrophic lateral sclerosis (ALS), we compared serum levels of alpha-carotene, beta-carotene, and retinol (vitamin A), measured by HPLC, in 40 patients with amyotrophic lateral sclerosis (ALS) and 87 matched controls using an isocratic high performance liquid chromatography technique. The mean serum alpha and beta-carotene, and retinol levels did not differ significantly between the 2 study groups. These values were not influenced by the clinical form (spinal vs bulbar) of ALS, and they did not correlate with age, age at onset, and duration of the disease. These results suggest that serum alpha and beta-carotene and retinol concentrations are unrelated with the risk for ALS.

摘要

为了阐明血清α-胡萝卜素、β-胡萝卜素和视黄醇水平是否与肌萎缩侧索硬化症（ALS）的风险相关，我们使用等度高效液相色谱技术，比较了40例肌萎缩侧索硬化症（ALS）患者和87例匹配对照者通过高效液相色谱法测定的血清α-胡萝卜素、β-胡萝卜素和视黄醇（维生素A）水平。两个研究组之间的血清α-胡萝卜素、β-胡萝卜素和视黄醇平均水平无显著差异。这些值不受ALS临床类型（脊髓型与延髓型）的影响，且与年龄、发病年龄和病程无关。这些结果表明，血清α-胡萝卜素、β-胡萝卜素和视黄醇浓度与ALS风险无关。