Sasaki H, Sekizawa K, Yanai M, Arai H, Yamaya M, Ohrui T
Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, Sendai, Japan.
Tohoku J Exp Med. 1998 Nov;186(3):151-67. doi: 10.1620/tjem.186.151.
Although both tobacco smoking and air pollution are believed to be environmental factors affecting the prevalence of chronic obstructive pulmonary disease (COPD) and bronchial asthma, the mechanisms by which they induce/aggravate these diseases are still not known in detail. While smoking has been demonstrated to cause and aggravate COPD and bronchial asthma, the influence of air pollution, suspected to have hazardous environmental effects since the historical episodes of severe air pollution such as the London Smog, on the prevalence of airway diseases remains unclear. This is due, in part, to changes over time in the nature of the air pollutants concerned. There have been no consistent findings on the effects on airway diseases of air pollutants at levels currently observed in developed countries. It is believed that cessation of smoking is the most important factor in preventing the development of COPD.
虽然吸烟和空气污染都被认为是影响慢性阻塞性肺疾病(COPD)和支气管哮喘患病率的环境因素,但其诱发/加重这些疾病的机制仍未完全明确。虽然吸烟已被证明会引发和加重COPD和支气管哮喘,但自伦敦烟雾等严重空气污染历史事件以来,空气污染被怀疑具有有害环境影响,其对气道疾病患病率的影响仍不明确。部分原因在于相关空气污染物的性质随时间发生了变化。对于发达国家目前观测到的空气污染物水平对气道疾病的影响,尚无一致的研究结果。人们认为戒烟是预防COPD发展的最重要因素。