法国出现多株对阿莫西林具有高水平耐药性的临床肺炎链球菌分离株克隆。
Emergence in france of multiple clones of clinical Streptococcus pneumoniae isolates with high-level resistance to amoxicillin.
作者信息
Doit C, Loukil C, Fitoussi F, Geslin P, Bingen E
机构信息
Laboratoire de Microbiologie, Hôpital Robert Debré, 75019 Paris, France.
出版信息
Antimicrob Agents Chemother. 1999 Jun;43(6):1480-3. doi: 10.1128/AAC.43.6.1480.
Abstract
The genetic relatedness of French isolates of Streptococcus pneumoniae highly resistant to amoxicillin (MIC, >/=4 microg/ml, equal to or exceeding those of penicillin) was investigated by molecular fingerprinting. The results suggest that high-level resistance to amoxicillin has emerged within preexisting penicillin-resistant clones.
摘要
通过分子指纹图谱技术对法国分离出的对阿莫西林高度耐药（最低抑菌浓度，≥4微克/毫升，等于或超过青霉素的最低抑菌浓度）的肺炎链球菌进行了遗传相关性研究。结果表明，对阿莫西林的高水平耐药性已在先前存在的耐青霉素克隆中出现。
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