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2
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本文引用的文献

1
High-level beta-lactam resistance in strains of Streptococcus pneumoniae isolated in the UK.在英国分离出的肺炎链球菌菌株中的高水平β-内酰胺耐药性。
J Antimicrob Chemother. 1998 Jul;42(1):115-6. doi: 10.1093/jac/42.1.115.
2
Trends in antimicrobial drug use in the community--France, 1981-1992.1981 - 1992年法国社区抗菌药物使用趋势
J Infect Dis. 1998 Feb;177(2):492-7. doi: 10.1086/517384.
3
Antibiotic-resistant pneumococci in pediatric disease.儿科疾病中的耐抗生素肺炎球菌
Microb Drug Resist. 1995 Spring;1(1):5-8. doi: 10.1089/mdr.1995.1.5.
4
Mechanisms of the spread of penicillin resistance in Streptococcus pneumoniae strains causing meningitis in children in France.法国儿童脑膜炎肺炎链球菌菌株中青霉素耐药性传播的机制
J Infect Dis. 1996 Sep;174(3):520-8. doi: 10.1093/infdis/174.3.520.
5
Antimicrobial resistance of Streptococcus pneumoniae recovered from outpatients in the United States during the winter months of 1994 to 1995: results of a 30-center national surveillance study.1994年至1995年冬季美国门诊患者中分离出的肺炎链球菌的耐药性：一项30中心全国监测研究的结果
Antimicrob Agents Chemother. 1996 May;40(5):1208-13. doi: 10.1128/AAC.40.5.1208.
6
Identification of multiple clones of extended-spectrum cephalosporin-resistant Streptococcus pneumoniae isolates in the United States.在美国对耐超广谱头孢菌素肺炎链球菌分离株的多个克隆进行鉴定。
Antimicrob Agents Chemother. 1995 Oct;39(10):2282-8. doi: 10.1128/AAC.39.10.2282.
7
Evidence for the introduction of a multiresistant clone of serotype 6B Streptococcus pneumoniae from Spain to Iceland in the late 1980s.20世纪80年代末，血清型6B肺炎链球菌多重耐药克隆从西班牙传入冰岛的证据。
J Infect Dis. 1993 Jul;168(1):158-63. doi: 10.1093/infdis/168.1.158.
8
In vitro killing activities of antibiotics at clinically achievable concentrations in cerebrospinal fluid against penicillin-resistant Streptococcus pneumoniae isolated from children with meningitis.脑脊液中临床可达到浓度的抗生素对从脑膜炎患儿分离出的耐青霉素肺炎链球菌的体外杀伤活性。
Antimicrob Agents Chemother. 1994 Nov;38(11):2655-9. doi: 10.1128/AAC.38.11.2655.
9
Diminished activity of ceftizoxime in comparison to cefotaxime and ceftriaxone against Streptococcus pneumoniae.与头孢噻肟和头孢曲松相比，头孢唑肟对肺炎链球菌的活性降低。
Clin Infect Dis. 1995 Mar;20(3):671-6. doi: 10.1093/clinids/20.3.671.
10
Comparative activity of ampicillin, amoxycillin, amoxycillin/clavulanate and cefotaxime against 189 penicillin-susceptible and -resistant pneumococci.氨苄西林、阿莫西林、阿莫西林/克拉维酸和头孢噻肟对189株青霉素敏感和耐药肺炎球菌的比较活性
J Antimicrob Chemother. 1995 Jun;35(6):883-8. doi: 10.1093/jac/35.6.883.

法国出现多株对阿莫西林具有高水平耐药性的临床肺炎链球菌分离株克隆。

Emergence in france of multiple clones of clinical Streptococcus pneumoniae isolates with high-level resistance to amoxicillin.

作者信息

Doit C, Loukil C, Fitoussi F, Geslin P, Bingen E

机构信息

Laboratoire de Microbiologie, Hôpital Robert Debré, 75019 Paris, France.

出版信息

Antimicrob Agents Chemother. 1999 Jun;43(6):1480-3. doi: 10.1128/AAC.43.6.1480.

DOI:10.1128/AAC.43.6.1480
PMID:10348775
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC89301/
Abstract

The genetic relatedness of French isolates of Streptococcus pneumoniae highly resistant to amoxicillin (MIC, >/=4 microg/ml, equal to or exceeding those of penicillin) was investigated by molecular fingerprinting. The results suggest that high-level resistance to amoxicillin has emerged within preexisting penicillin-resistant clones.

摘要

通过分子指纹图谱技术对法国分离出的对阿莫西林高度耐药（最低抑菌浓度，≥4微克/毫升，等于或超过青霉素的最低抑菌浓度）的肺炎链球菌进行了遗传相关性研究。结果表明，对阿莫西林的高水平耐药性已在先前存在的耐青霉素克隆中出现。